Results of trabeculectomy with adjunctive intraoperative mitomycin C in Chinese patients with glaucoma

• Published in: Ophthalmic surgery, lasers & imaging Vol. 37; no. 1; p. 33
• Main Authors: Tham, Clement C Y, Lai, Jimmy S M, Poon, Agnes S Y, Lai, Timothy Y Y, Lam, Dennis S C
• Format: Journal Article
• Language: English
• Published: United States 01-01-2006
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Asian Continental Ancestry Group; Child; Child, Preschool; Female; Follow-Up Studies; Glaucoma - drug therapy; Glaucoma - physiopathology; Glaucoma - surgery; Hong Kong - epidemiology; Humans; Incidence; Intraocular Pressure; Intraoperative Period; Male; Middle Aged; Mitomycin - administration & dosage; Mitomycin - therapeutic use; Nucleic Acid Synthesis Inhibitors - administration & dosage; Nucleic Acid Synthesis Inhibitors - therapeutic use; Ophthalmic Solutions; Postoperative Complications - epidemiology; Postoperative Complications - prevention & control; Retrospective Studies; Trabeculectomy - methods; Treatment Outcome; Hong Kong
• ISSN: 1542-8877
• DOI: 10.3928/1542-8877-20060101-07

To report the results of trabeculectomy with adjunctive intraoperative mitomycin C in Chinese patients with glaucoma.
The medical records of Chinese patients who received trabeculectomy with intraoperative mitomycin C from 1992 to 1998 were retrospectively reviewed. A "successful" trabeculectomy was defined as one after which the intraocular pressure (IOP) could be controlled to between 5 and 21 mm Hg, inclusive, with no more than 3 glaucoma medications.
One hundred fourteen trabeculectomies in 105 eyes of 90 patients were retrospectively reviewed. Mean age +/- standard deviation was 48.1 +/- 21.9 years. Primary open-angle glaucoma (43.0%) and angle-closure glaucoma (27.2%) were the most common diagnoses leading to trabeculectomy. The mean follow-up +/- standard deviation was 29.6 +/- 18.6 months (range, 6 to 92 months). The overall success rate at the last follow-up was 73.7% (84 of 114 trabeculectomies).
Trabeculectomy with mitomycin C is a safe and effective procedure for the control of IOP in Chinese patients with glaucoma.