The role of circadian genes in the pathogenesis of colorectal cancer

• Published in: Gene Vol. 804; p. 145894
• Main Authors: Razi Soofiyani, Saiedeh, Ahangari, Hossein, Soleimanian, Alireza, Babaei, Ghader, Ghasemnejad, Tohid, Safavi, Seyed Esmaeil, Eyvazi, Shirin, Tarhriz, Vahideh
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15-12-2021
• Subjects: Bmal1; Circadian rhythm; CLOCK gene; Colorectal cancer (CRC); Timeless; T2DM; CLK; HDAC3; Bmal1; NPAS2; ARNTL; Aβ; DBP; SNP; FASPD; Timeless; CIMP; CLOCk; Colorectal cancer (CRC); MSI; AD; DSPD; CIN; CSNK1E; Circadian rhythm; CK1d/ε; AF2; PPARγ; PER2; PP1; PER1; CLOCK gene; NCOR1; PER3; APC; Dec1/2; CRC; BPD; CRY2; SAD; CRY1; TIM; SCN
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2021.145894

•The circadian system plays a significant role in gastrointestinal physiology.•The circadian genes expression is frequently changed in colorectal cancers.•The circadian genes expression affects the phenotype of colon neoplastic cells.•The circadian genes expression affects chemotherapy response in colorectal cancer.
Colorectal cancer (CRC) is the third most frequent cancer in human beings and is also the major cause of death among the other gastrointestinal cancers. The exact mechanisms of CRC development in most patients remains unclear. So far, several genetically, environmental and epigenetically risk factors have been identified for CRC development. The circadian rhythm is a 24-h rhythm that drives several biologic processes. The circadian system is guided by a central pacemaker which is located in the suprachiasmatic nucleus (SCN) in the hypothalamus. Circadian rhythm is regulated by circadian clock genes, cytokines and hormones like melatonin. Disruptions in biological rhythms are known to be strongly associated with several diseases, including cancer. The role of the different circadian genes has been verified in various cancers, however, the pathways of different circadian genes in the pathogenesis of CRC are less investigated. Identification of the details of the pathways in CRC helps researchers to explore new therapies for the malignancy.