Effect of Apple (Malus domestica) Stem Cells on UVB-Induced Damage Skin with Anti-Inflammatory Properties: An In Vivo Study

• Published in: Advances in materials science and engineering Vol. 2022; pp. 1 - 13
• Main Authors: Khayatan, Danial, Nilforoushzadeh, Mohammad Ali, Ahmadi Ashtiani, Hamid Reza, Hashemian, Farshad
• Format: Journal Article
• Language: English
• Published: New York Hindawi 19-03-2022; Hindawi Limited
• Subjects: Apoptosis; Apples; Biometrics; Cytokines; Damage; Dermatitis; Drug dosages; Epidermis; In vivo methods and tests; Inflammation; Laboratory animals; Melanin; Moisture content; Moisture effects; Nonsteroidal anti-inflammatory drugs; Signal transduction; Skin diseases; Stem cells; Tumor necrosis factor-TNF; Ultraviolet radiation; United States > US; Germany
• ISSN: 1687-8434; 1687-8442
• DOI: 10.1155/2022/2417766

Objective. Apple (Malusdomesticus) stem cells have beneficial effects in preventing photodamages caused by UVB responsible for inflammation in different stages of various skin disorders. This study aimed to investigate Apple stem cells’ anti-inflammatory and repairing effects on UVB-induced rat dorsal skin damage via microscopic and macroscopic analyses. Materials and Methods. Therapeutic effects of the apple stem cells (ASCs) extract were evaluated after UVB irradiation with macroscopic and microscopic studies, including pathological analysis, inflammatory cytokines measuring, and biometric studies containing investigation of thickness, density, erythema, melanin, sebum, and moisture content of epidermis and dermis layers in rat models. After biometric studies, skin samples were taken for histopathologic and biochemical analyses. Results. ASC extract could attenuate infiltration of inflammatory cells caused by UVB and ameliorate collagen regulation of the photodamaged skin. In addition, improved skin biometrics was considerable, such as reducing thickened epidermal and dermal layers compared to other rat groups. Furthermore, moisture content enhancement of the skin showed clinical advantages in treating damages and inflammation. Furthermore, TNF-α expression was downregulated after ASC application. ASC extract could treat UVB damages and indicate anti-inflammatory effects in animal models. Conclusion. The ASCs can be an appropriate candidate for treating inflammation and damages induced by UVB in clinical studies.