The Role of Vitamin D Receptor Polymorphisms on Dental Caries

To determine the association between the ApaI, FokI, Cdx2 and TaqI polymorphisms of vitamin D receptor (VDR) gene in caries-active (high-moderate) and caries-free children. A hundred and fifty children (75 males, 75 females, mean age: 10.19 ± 1.61 years) were included in the study. The subjects were...

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Bibliographic Details
Published in:	The Journal of clinical pediatric dentistry Vol. 40; no. 3; p. 211
Main Authors:	Cogulu, Dilsah, Onay, Huseyin, Ozdemir, Yasemin, Aslan, Gulcin Itirli, Ozkinay, Ferda, Eronat, Cemal
Format:	Journal Article
Language:	English
Published:	United States 01-01-2016
Subjects:	CDX2 Transcription Factor - genetics Child Dental Caries - genetics Dental Plaque Index Deoxyribonucleases, Type II Site-Specific - genetics Dietary Sucrose - administration & dosage Female Gene Frequency - genetics Genetic Predisposition to Disease - genetics Genotype Humans Male Polymorphism, Genetic - genetics Polymorphism, Restriction Fragment Length - genetics Receptors, Calcitriol - genetics Toothbrushing - methods Transcription Factors - genetics dental caries Vitamin D receptor polymorphism
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Summary:	To determine the association between the ApaI, FokI, Cdx2 and TaqI polymorphisms of vitamin D receptor (VDR) gene in caries-active (high-moderate) and caries-free children. A hundred and fifty children (75 males, 75 females, mean age: 10.19 ± 1.61 years) were included in the study. The subjects were divided into three groups as high caries risk group (DMFT, dft>4)(n=55), moderate caries risk group (DMFT, dft=1-4)(n=57) and caries-free group (n=38). From each individual, blood samples were collected and DNA was extracted. The VDR gene was genotyped for the polymorphisms ApaI, FokI, Cdx2 and TaqI using polymerase chain reaction and restriction fragment length polymorphism methods. All data were analyzed by chi-square test, Fisher's exact test and t test. There was statistically significant difference in the frequency of TaqI genotypes (tt) between caries-active and caries-free children (p=0.029). No statistically significant differences were detected between ApaI, FokI, Cdx2 genotypes and dental caries. In the future, VDR gene polymorphisms may be used as a marker for the identification of patients with high caries risk.
ISSN:	1053-4628
DOI:	10.17796/1053-4628-40.3.211