Rapid and Efficient Uncatalyzed Knoevenagel Condensations from Binary Mixture of Ethanol and Water

This paper presents a new green protocol for Knoevenagel condensations of aldehydes and compounds with an active methylene group in a binary mixture of ethanol/water (3:7, v/v). This medium favored the uncatalyzed Knoevenagel reactions and easy workup products can be obtained by precipitation in thi...

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Bibliographic Details
Published in:	Journal of the Brazilian Chemical Society Vol. 29; no. 7; pp. 1382 - 1387
Main Authors:	Ferreira, João, de Resende Filho, João, Batista, Poliane, Teotonio, Ercules, Vale, Juliana
Format:	Journal Article
Language:	English
Published:	Sociedade Brasileira de Química 01-07-2018
Subjects:	CHEMISTRY, MULTIDISCIPLINARY binary mixture active methylene compounds and aldehydes green approach Knoevenagel condensation ethanol/water
Online Access:	Get full text
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Summary:	This paper presents a new green protocol for Knoevenagel condensations of aldehydes and compounds with an active methylene group in a binary mixture of ethanol/water (3:7, v/v). This medium favored the uncatalyzed Knoevenagel reactions and easy workup products can be obtained by precipitation in this medium and showed good isolated yields (55-100%) in short reaction times (1-60 min).
ISSN:	0103-5053 1678-4790 1678-4790
DOI:	10.21577/0103-5053.20170240