Synthesis and immunomodulatory activity of novel amino acid analogues of fluoxetine

• Published in: Synthetic communications Vol. 53; no. 10; pp. 731 - 743
• Main Authors: Talati, Mamta N., Vemireddy, Sravanthi, Seelam, Siva Deepthi, Halmuthur. M., Sampath Kumar
• Format: Journal Article
• Language: English
• Published: Philadelphia Taylor & Francis 19-05-2023; Taylor & Francis Ltd
• Subjects: Amino acids; Autoimmune diseases; Chemical synthesis; Fluoxetine; IL-10; Immunomodulators; Lymphocytes; Mitsunobu reaction; T cell proliferation inhibitors
• ISSN: 0039-7911; 1532-2432
• DOI: 10.1080/00397911.2023.2196024

Immunomodulators are assigned as a robust tool for the treatment of various medical conditions like AIDS, cancer and autoimmune diseases. In this work, we have synthesized a series of fluoxetine-based small-molecule immunomodulators. Molecules were synthesized by a convergent strategy, where mitsunobu reaction was conducted to synthesize the common starting material. The novel analogues displayed immunomodulatory potential as indicated by the anti-inflammatory effect derived through the compound's T cell proliferation inhibitory property. The synthesized novel analogues manifested encouraging biological responses, assure their application as immunomodulators.