Database of radiogenic cancer in experimental animals exposed to low doses of ionizing radiation

• Published in: Journal of toxicology and environmental health. Part B, Critical reviews Vol. 15; no. 3; pp. 186 - 209
• Main Authors: Duport, Philippe, Jiang, Huixia, Shilnikova, Natalia S, Krewski, Daniel, Zielinski, Jan M
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Ltd 01-04-2012
• Subjects: Animals; Cancer; Databases, Factual; Dose-Response Relationship, Radiation; Epidemiology; Hormesis; Mammals; Neoplasms, Radiation-Induced; Radiation therapy; Radiation, Ionizing; Risk assessment
• ISSN: 1093-7404; 1521-6950
• DOI: 10.1080/10937404.2012.659136

For decades, there have been debates regarding the nature of the relationship between exposure to low doses of ionizing radiation and cancer risk. Under the linear no-threshold hypothesis, which serves as a theoretical basis for current radiation protection standards, the risk of cancer at low levels of exposure is presumed to be directly proportional to dose. Opponents of this hypothesis claim that there are threshold doses for radiation carcinogenesis, or even a reduction in cancer risk at low doses (a phenomenon referred to as "radiation hormesis"). Epidemiological, animal, molecular, and cellular studies were conducted to resolve this controversy, although each of these study types has its strengths and limitations. Although the results of animal experiments are not directly applicable to humans, data can substantially add to our knowledge on the form of relationship between radiation dose and cancer risk in a wide range of doses. Laboratory animals are a homogeneous population with little biological variability; animal experiments are conducted under controlled conditions with good estimates of radiation doses. In order to address the question of whether or not the dose-response curve for radiation carcinogens is linear at low doses, a comprehensive database of animal carcinogenesis experiments was assembled involving exposure to different types of ionizing gradation. The database includes virtually all publicly accessible data on the induction of radiogenic cancer in laboratory mammals. This review provides a descriptive overview of the experiments included in the database, along with a qualitative assessment of the shape of the dose-response relationship for radiation carcinogenesis at low doses in experimental animals.