Histopathological and cytological correlation of tumors of breast

• Published in: Medical Journal of Dr. D.Y. Patil University Vol. 7; no. 3; pp. 326 - 331
• Main Authors: Sushma Yalavarthi, Ramamurti Tanikella, Shailaja Prabhala, Uma Shankar Tallam
• Format: Journal Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 01-05-2014
• Subjects: Breast tumors; fine needle aspiration cytology; histopathology; proliferative lesions
• ISSN: 0975-2870
• DOI: 10.4103/0975-2870.128975

Background :0 With the advent of fine needle aspiration cytology (FNAC), the approach to diagnosis and management of breast lesions has been revolutionized. Its accuracy in many situations can approach that of histopathology in providing an unequivocal diagnosis. Aim :0 The aim of this study is to examine the cytological details in aspirated smears from lumps in the breast and to evaluate the role of FNAC in improving the quality of diagnosis by comparing with histopathological features. Materials and Methods: Over a period of 2 years, 334 aspirations, including 16 bilateral were performed. Suppurative and inflammatory lesions and gynecomastia were excluded from the total aspirates. A total of 56 cases were followed-up by histopathologic examination. Results: Cytohistologic correlation was 73.68%, 42.85%, 94.44% for fibroadenoma, fibrocystic disease and duct cell carcinoma respectively. False positives were observed in proliferative lesions. No false negative cases observed. The sensitivity of the fine needle aspiration (FNA) procedure was 100%, specificity, 88.5% and the predictive value of a positive result was 84%. Conclusion: Proliferative lesions may be misinterpreted as malignancy in FNA without complete clinical and mammographic details.