Gene delivery systems for gene therapy in tissue engineering and central nervous system applications

The present review aims to describe the potential applications of gene delivery systems to tissue engineering and central nervous system diseases. Some key experimental work has been done with interesting results, but the subject is far from being fully explored. The combined approach of gene therap...

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Bibliographic Details
Published in:	International journal of artificial organs Vol. 31; no. 12; pp. 1017 - 1026
Main Authors:	Giordano, C, Causa, F, Bianco, F, Perale, G, Netti, P A, Ambrosio, L, Cigada, A
Format:	Journal Article
Language:	English
Published:	United States 01-12-2008
Subjects:	Biocompatible Materials Central Nervous System Diseases - therapy Gene Transfer Techniques Genetic Therapy Humans Polymers Tissue Engineering
Online Access:	Get full text
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Summary:	The present review aims to describe the potential applications of gene delivery systems to tissue engineering and central nervous system diseases. Some key experimental work has been done with interesting results, but the subject is far from being fully explored. The combined approach of gene therapy and material science has a huge potential to improve the therapeutic approaches now available for a wide range of medical applications. Focus is given to this multidisciplinary strategy in neurodegenerative pathologies, where the use of polymeric matrices as gene carriers might make a crucial difference.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	0391-3988 1724-6040
DOI:	10.1177/039139880803101205