1,2,4,5-Tetraoxacycloalkanes: synthesis and antimalarial activity

In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.

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Bibliographic Details
Published in:	Mini reviews in medicinal chemistry Vol. 5; no. 11; p. 1035
Main Authors:	Masuyama, A, Wu, J-M, Nojima, M, Kim, H-S, Wataya, Y
Format:	Journal Article
Language:	English
Published:	Netherlands 01-11-2005
Subjects:	Animals Antimalarials - chemical synthesis Antimalarials - pharmacology Cycloparaffins - chemical synthesis Cycloparaffins - pharmacology Drug Design Humans
Online Access:	Get more information
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Description
Summary:	In this short review the methods of preparation of novel 1,2,4,5-tetraoxacycloalkanes and the related peroxides are summarized, with the emphasis on the usefulness of 1,1-bishydroperoxides as the precursor. Also, their antimalarial activities in vitro and in vivo are discussed.
ISSN:	1389-5575
DOI:	10.2174/138955705774575255