Histoplasma capsulatum fungemia in patients with acquired immunodeficiency syndrome : Detection by lysis-centrifugation blood-culturing technique

• Published in: Revista do Instituto de Medicina Tropical de São Paulo Vol. 49; no. 3; pp. 135 - 138
• Main Authors: OLIVEIRA, Flavio De Mattos, FERNANDES, Sérgio Sonego, SEVERO, Cecilia Bittencourt, GUAZZELLI, Luciana Silva, SEVERO, Luiz Carlos
• Format: Journal Article
• Language: English
• Published: São Paulo Instituto de Medicina Tropical de São Paulo 01-05-2007; Instituto de Medicina Tropical de Sao Paulo
• Subjects: Adult; AIDS-Related Opportunistic Infections - diagnosis; AIDS-Related Opportunistic Infections - microbiology; Biological and medical sciences; Centrifugation - methods; Culture Techniques; Female; Fungemia - diagnosis; Fungemia - microbiology; General aspects; Histoplasma - classification; Histoplasma - isolation & purification; Histoplasmosis - diagnosis; Histoplasmosis - microbiology; Human mycoses; Human viral diseases; Humans; Infectious diseases; Male; Medical sciences; Mycoses; Mycotic sepsis; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Human; Immunopathology; Histoplasmosis; Mycosis; Histoplasma capsulatum; Patient; AIDS; Immune deficiency; Lysis-centrifugation; Blood; Fungi; Infection; Fungemia; Viral disease; Tropical medicine; Fungi Imperfecti; Technique; Detection; Thallophyta
• ISSN: 0036-4665; 1678-9946; 0036-4665
• DOI: 10.1590/S0036-46652007000300001

Progressive disseminated histoplasmosis (PDH) is an increasingly common cause of infection in patients with acquired immune deficiency syndrome (AIDS). We report 21 cases of PDH associated with AIDS diagnosed by lysis-centrifugation blood culture method. The most prevalent clinical findings were fever, weight loss, respiratory symptoms, and mucocutaneous lesions. Chest roentgenogram showed diffuse pulmonary infiltrates in 13 of 21 patients (62%). Bronchoalveolar fluid has yielded positive culture in four patients only in medium with cycloheximide.