Frequency of various types of neoplasia in a group of acromegalic patients

• Published in: Arquivos brasileiros de endocrinologia e metabologia Vol. 57; no. 8; pp. 612 - 616
• Main Authors: Bolfi, Fernanda, Miot, Helio Amante, Resende, Mariangela, Mazeto, Glaucia M S F, Romeiro, Fernando Gomes, Yamashiro, Fábio da Silva, Nunes, Vânia dos Santos
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Endocrinologia e Metabologia 01-11-2013
• Subjects: Acanthosis Nigricans - diagnosis; Acromegaly - blood; Acromegaly - complications; Adenocarcinoma - diagnosis; Adenocarcinoma - epidemiology; Adult; Aged; Colonic Neoplasms - diagnosis; Colonic Neoplasms - epidemiology; ENDOCRINOLOGY & METABOLISM; Female; Humans; Hyperparathyroidism, Primary - diagnosis; Hyperparathyroidism, Primary - epidemiology; Insulin-Like Growth Factor I - analysis; Male; Middle Aged; Retrospective Studies; Skin Neoplasms - diagnosis; Skin Neoplasms - epidemiology; Thyroid Nodule - diagnosis; Thyroid Nodule - epidemiology; câncer de cólon; colonic neoplasms; câncer de tireoide; Acromegaly; primary hyperparathyroidism; thyroid neoplasms; hiperparatireoidismo primário; Acromegalia
• ISSN: 0004-2730; 1677-9487; 1677-9487; 0004-2730
• DOI: 10.1590/S0004-27302013000800005

To determine the frequency of colon cancer, primary hyperparathyroidism, thyroid tumor, and skin cancer in all acromegalic patients in follow-up at the Clinics Hospital - Botucatu Medical School, from 2005 to 2011.
These patients were evaluated retrospectively for colon cancer, primary hyperparathyroidism, dermatological, and thyroid tumors.
Of 29 patients included at the beginning of the study, two were excluded. Among 19 patients submitted to colonoscopy, one presented colon adenocarcinoma (5%). Thyroid nodules were present in 63% of patients, and papilliferous carcinoma was confirmed in two patients (7,7%). Four patients were confirmed as having primary hyperparathyroidism (15%). The most common dermatologic lesions were thickened skin (100%), acrochordons (64%), epidermal cysts (50%), and pseudo-acanthosis nigricans (50%). Only one patient presented basal cell carcinoma.
Although a small number of acromegalic patients was studied, our findings confirm the high frequency of thyroid neoplasias and primary hyperparathyroidism in this group of patients.