A review of the isolated kidney as an experimental model for pharmacokinetic studies

Traditional distribution studies have been based on methods affording steady-state partition coefficient or sparsely defined tissue profiles. Isolation organ techniques provide a methodology for complete description of drug disposition at any particular tissue; the kidney constitutes a case for impo...

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Bibliographic Details
Published in:	Methods and findings in experimental and clinical pharmacology Vol. 22; no. 10; pp. 757 - 763
Main Authors:	ZARZUELO, A, SANCHEZ-NAVARRO, A, LOPEZ, F. G, LANAO, J. M
Format:	Journal Article
Language:	English
Published:	Barcelona Prous 01-12-2000
Subjects:	Animals Biological and medical sciences Drug Interactions General pharmacology In Vitro Techniques Inactivation, Metabolic Kidney - metabolism Kidney - surgery Medical sciences Perfusion - methods Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Tissue Distribution Drug Drug combination Methodology Elimination Review Metabolism Kidney Isolated organ Urinary system Animal Distribution Drug interaction Pharmacokinetics
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