A review of the isolated kidney as an experimental model for pharmacokinetic studies

• Published in: Methods and findings in experimental and clinical pharmacology Vol. 22; no. 10; pp. 757 - 763
• Main Authors: ZARZUELO, A, SANCHEZ-NAVARRO, A, LOPEZ, F. G, LANAO, J. M
• Format: Journal Article
• Language: English
• Published: Barcelona Prous 01-12-2000
• Subjects: Animals; Biological and medical sciences; Drug Interactions; General pharmacology; In Vitro Techniques; Inactivation, Metabolic; Kidney - metabolism; Kidney - surgery; Medical sciences; Perfusion - methods; Pharmacokinetics; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Tissue Distribution; Drug; Drug combination; Methodology; Elimination; Review; Metabolism; Kidney; Isolated organ; Urinary system; Animal; Distribution; Drug interaction; Pharmacokinetics
• ISSN: 0379-0355
• DOI: 10.1358/mf.2000.22.10.802294

Traditional distribution studies have been based on methods affording steady-state partition coefficient or sparsely defined tissue profiles. Isolation organ techniques provide a methodology for complete description of drug disposition at any particular tissue; the kidney constitutes a case for importance for those drugs eliminated by renal excretion of those whose toxicological or pharmacological target space is located at this level. The aim of the present review is to analyze the use of the isolated perfused kidney in pharmacokinetic studies and its potential in this field.