The plasticity of nerve fibers: the prolonged effects of polarization of afferent fibers

• Published in: Journal of neurophysiology Vol. 126; no. 5; pp. 1568 - 1591
• Main Authors: Jankowska, Elzbieta, Hammar, Ingela
• Format: Journal Article
• Language: English
• Published: United States 01-11-2021
• Subjects: afferent fibers; Animals; direct-current stimulation; dorsal-horn; electrical-stimulation; Electrophysiological Phenomena - physiology; epidural; Epidural Space - physiology; epidural stimulation; facilitation; gaba(a) receptor subtypes; human lumbosacral cord; ii muscle afferents; long-term; motor control; motor cortex; Motor Neurons - physiology; Nerve Fibers, Myelinated - physiology; Neuronal Plasticity - physiology; neurons; Neurons, Afferent - physiology; Neurosciences; Neurosciences & Neurology; Neurovetenskaper; Physiology; polarization; posterior structures; spinal cord; Spinal Cord - physiology; spinal direct-current; Transcranial Direct Current Stimulation; polarization; afferent fibers; spinal cord; motor control; epidural stimulation
• ISSN: 0022-3077; 1522-1598
• DOI: 10.1152/jn.00718.2020

The review surveys various aspects of the plasticity of nerve fibers, in particular the prolonged increase in their excitability evoked by polarization, focusing on a long-lasting increase in the excitability of myelinated afferent fibers traversing the dorsal columns of the spinal cord. We review the evidence that increased axonal excitability
) follows epidurally applied direct current (DC) as well as relatively short (5 or 10 ms) current pulses and synaptically evoked intrinsic field potentials;
) critically depends on the polarization of branching regions of afferent fibers at the sites where they bifurcate and give off axon collaterals entering the spinal gray matter in conjunction with actions of extrasynaptic GABA
membrane receptors; and
) shares the feature of being activity-independent with the short-lasting effects of polarization of peripheral nerve fibers. A comparison between the polarization evoked sustained increase in the excitability of dorsal column fibers and spinal motoneurons (plateau potentials) indicates the possibility that they are mediated by partly similar membrane channels (including noninactivating type L Cav
1.3 but not Na
channels) and partly different mechanisms. We finally consider under which conditions transspinally applied DC (tsDCS) might reproduce the effects of epidural polarization on dorsal column fibers and the possible advantages of increased excitability of afferent fibers for the rehabilitation of motor and sensory functions after spinal cord injuries.
This review supplements previous reviews of properties of nerve fibers by surveying recent experimental evidence for their long-term plasticity. It also extends recent descriptions of spinal effects of DC by reviewing effects of polarization of afferent nerve fibers within the dorsal columns, the mechanisms most likely underlying the long-lasting increase in their excitability and possible clinical implications.