Neurophysiological evaluation of juvenile systemic lupus erythematosus

• Published in: Egyptian Rheumatology and Rehabilitation Vol. 49; no. 1; pp. 1 - 9
• Main Authors: Thabet, Alaa M., Elnwam, Sara A., Mekky, Jaidaa F., Abdelghany, Hayam M., Fathy, Hanan M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 11-07-2022; SpringerOpen
• Subjects: Medicine; Medicine & Public Health; Nerve conduction study; Neurologic manifestations; Rehabilitation; Systemic lupus erythematosus; Nerve conduction study; Neurologic manifestations; Systemic lupus erythematosus
• ISSN: 1110-161X; 2090-3235
• DOI: 10.1186/s43166-022-00141-1

Background
Peripheral nervous system and the central nervous system involvement in systemic lupus erythematosus (SLE) patients are one of the major causes of morbidity and mortality. The aim of this work was to study the nervous system clinically and electrophysiologically in children with systemic lupus erythematosus.
Results
The study was carried out on thirty-eight children with SLE. Their age ranged from 5 to 16 years. The most encountered neurologic manifestations were tremors. It was observed in 47.4% of children, followed by headache in 39.5%, sensory manifestation as numbness in 23.7%, cerebrovascular stroke in 5.3%, and chorea in 2.6%, which was unilateral mostly in the upper limb, tics, and convulsion had the same percentage. Around 16% of children had positive findings in MRI, such as cerebrovascular disease, minimal hematoma, pseudotumorcerebri, vasculitis, and ectatic ventricles. Subclinical peripheral neuropathy was reported in nearly 52.6% of children, and clinical peripheral neuropathy was reported in 23.6%. Pure sensory subclinical peripheral neuropathy was detected in 13.1% of children, but mixed subclinical peripheral neuropathy was detected in 39.4%. Nearly 53% of studied children had an abnormal somatosensory-evoked potential study of posterior tibial and median nerves.
Conclusion
The current study reported that the clinical neurological manifestations in juvenile SLE is common. Peripheral neuropathy is commonly detected, which could be either clinical or sub-clinical. Somatosensory evoked potential study is of value for early detection of central affection.
So, we recommend more studies to determine the guidelines when to order these informative investigations for children with JSLE.