Fabrication of a highly selective and sensitive voltammetric ganciclovir sensor based on electropolymerized molecularly imprinted polymer and gold nanoparticles on multiwall carbon nanotubes/glassy carbon electrode

• Published in: Sensors and actuators. B, Chemical Vol. 215; pp. 471 - 479
• Main Authors: Gholivand, M.B., Karimian, N.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-08-2015
• Subjects: Au nanoparticles; Electrochemical impedance spectroscopy; Electrodes; Electropolymerization; Ganciclovir; Glassy carbon; Gold; Imprinted polymers; Molecularly imprinted polymer; Multi wall carbon nanotubes; Polymerization; Sensors; Au nanoparticles; Ganciclovir; Molecularly imprinted polymer; Electropolymerization
• ISSN: 0925-4005; 1873-3077
• DOI: 10.1016/j.snb.2015.04.007

•The determination of ganciclovir using AuNPs-MIP/MWCNTs/GCE is reported for the first time.•The designed sensor based on molecularly imprinted polymer composed from 2,2′-dithiobenzidine and gold nanoparticles film at the surface of glassy carbon electrode modified with carboxyl-functionalized multiwall carbon nanotubes.•The developed sensor has been applied to determine ganciclovir in real samples.
For the first time, a new selective and sensitive voltammetric sensor for the determination of ganciclovir (GCV) based on electropolymerization of molecularly imprinted polymer (MIP) with gold nanoparticles (AuNPs) onto multiwalled carbon nanotubes (MWCNTs)/glassy carbon electrode has been developed. AuNPs were introduced into the polymer composite for the development of electrical response by facilitating the charge transfer process. During the course of electropolymerization, a functional monomer of 2,2′-dithiodianiline was combined with AuNPs through Au–S bonds. Modifications were characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and scanning electron microscopy (SEM) techniques. This sensor selectively detects ganciclovir even in the presence of high concentration of similar compounds. Under optimized conditions, the differential pulse voltammetric response was linearly related to ganciclovir concentrations between 0.05–50 and 50–500μM, with a limit of detection (LOD) of 0.0015μM. Moreover, the designed sensor exhibited long-term stability, good repeatability, reproducibility and sensitivity toward ganciclovir determination in human serum samples.