Synthesis and antiviral activities of novel 1,4-pentadien-3-one derivatives bearing an emodin moiety

• Published in: Chinese chemical letters Vol. 27; no. 6; pp. 948 - 952
• Main Authors: Wu, Jian, Zhu, Yun-Ying, Zhao, Yong-Hui, Shan, Wei-Li, Hu, De-Yu, Chen, Ji-Xiang, Liu, Deng-Yue, Li, Xiang-Yang, Yang, Song
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-06-2016
• Subjects: 1,4-Pentadien-3-one derivatives; Antiviral activity; Emodin; Synthesis; 合成; 大黄素; 天然产品; 戊二烯; 抗病毒活性; 烟草花叶病毒; 酮类衍生物; 黄瓜花叶病毒; Emodin; Synthesis; 1,4-Pentadien-3-one derivatives; Antiviral activity
• ISSN: 1001-8417; 1878-5964
• DOI: 10.1016/j.cclet.2016.01.051

A series of 1,5-diaryl-1,4-pentadien-3-one derivatives bearing an emodin group were designed and synthesized by the combination of natural products. The antiviral activities against tobacco mosaic virus（TMV） and cucumber mosaic virus（CMV） in vivo were evaluated. Some of the derivatives displayed promising curative effect and protective activity against TMV. Compound D5 showed appreciable curative bioactivity on TMV approximately of 50% at 306.2 mg/m L, which was superior to ningnanmycin（409.3 mg/m L）.