Does chromatin function as a metabolite reservoir?

Alternative histone acylations integrate gene expression with cellular metabolic states. Recent measurements of cellular acyl-coenzyme A (acyl-CoA) pools highlight the potential that histone post-translational modifications (PTMs) contribute directly to the regulation of metabolite pools. A metaboli...

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Bibliographic Details
Published in:	Trends in biochemical sciences (Amsterdam. Regular ed.) Vol. 47; no. 9; pp. 732 - 735
Main Authors:	Nirello, Vinícius D., Rodrigues de Paula, Dieggo, Araújo, Nathália V.P., Varga-Weisz, Patrick D.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-09-2022
Subjects:	Acyl Coenzyme A - metabolism acyl-CoA Acylation acylations Chromatin histone modifications Histones - metabolism metabolism Protein Processing, Post-Translational quiescence acyl-CoA quiescence metabolism histone modifications chromatin acylations
Online Access:	Get full text
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Summary:	Alternative histone acylations integrate gene expression with cellular metabolic states. Recent measurements of cellular acyl-coenzyme A (acyl-CoA) pools highlight the potential that histone post-translational modifications (PTMs) contribute directly to the regulation of metabolite pools. A metabolite-centric view throws new light onto roles and evolution of histone PTMs.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0968-0004 1362-4326
DOI:	10.1016/j.tibs.2022.03.016