Epidemiology, Predisposing Factors, and Outcomes of Drug-Induced Liver Injury

Epidemiology, Predisposing Factors, and Outcomes of Drug-Induced Liver Injury

Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. A recent population-based study found a crude incidence of approximately 19 cases per 100,000 a year. Amoxicillin-clavulanate continues to be the most commonly implicated agent in most Wester...

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Bibliographic Details
Published in:Clinics in liver disease Vol. 24; no. 1; pp. 1 - 10
Main Author: Björnsson, Einar S.
Format: Journal Article
Language:English
Published: Elsevier Inc 01-02-2020
Subjects:
Drug-induced liver injury
Epidemiology
Prognosis
Risk factors
Drug-induced liver injury
Prognosis
Epidemiology
Risk factors
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Summary:Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. A recent population-based study found a crude incidence of approximately 19 cases per 100,000 a year. Amoxicillin-clavulanate continues to be the most commonly implicated agent in most Western countries, reported to occur in approximately 1 of 2300 users. In patients with drug-induced autoimmune hepatitis, liver tests often do not normalize with cessation of the drugs and require corticosteroids. DILI associated with jaundice can lead to death from liver failure or require liver transplantation in at least 10% of cases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1089-3261
1557-8224
DOI:10.1016/j.cld.2019.08.002