Magnetically Recoverable Catalysts: Catalysis in Synthesis of Polyhydroquinolines

• Published in: Applied organometallic chemistry Vol. 34; no. 3
• Main Authors: Kazemi, Mosstafa, Mohammadi, Masoud
• Format: Journal Article
• Language: English
• Published: Chichester Wiley Subscription Services, Inc 01-03-2020
• Subjects: Calcium channel blockers; Catalysis; Catalysts; Chemical synthesis; Chemistry; Chemists; Hantzsch reaction; Magnetic nanoparticles; Magnetic separation; Multicomponent reaction; Nano catalyst; Organic chemistry; Polyhydroquinoline; Scaffolds
• ISSN: 0268-2605; 1099-0739
• DOI: 10.1002/aoc.5400

Molecules that contain polyhydroquinoline structural scaffolds are N‐containing heterocycles which are of great interest to organic chemists and biologists. Polyhydroquinoline structural scaffolds which are known as calcium channel blockers have emerged as one of the most important class of drugs used for the treatment of cardiovascular and Alzheimer's diseases. Besides, recovery and reusability of catalysts are important issues to be discussed in modern catalysis research especially in organic synthesis. The concept of magnetically recoverable catalysts has been rapidly developed in recent times. Magnetic separation is an efficient strategy for the rapid separation of catalysts from the reaction medium. Also, an alternative to time‐, solvent‐, and energy‐consuming separation techniques. In this review, we focused on the fabrication, surface‐modification and characterization of nanomagnetic materials and their application, as magnetically recoverable catalysts, in the synthesis of polyhydroquinoline structural scaffolds.
In this review, the surface modification and characterization of nanomagnetic materials and their application as magnetically recoverable catalysts in the synthesis of polyhydroquinoline structural scaffolds as a very interesting class of oxygen and nitrogen heterocycles that exhibit wide spectrum of biological and pharmacological activities was reviewed. We believe that the present review could be an important reference for the methodologists.