Spike Phase Shift Relative to Beta Oscillations Mediates Modality Selection

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 30; no. 10; pp. 5431 - 5448
• Main Authors: Zuo, Yanfang, Huang, Yanwang, Wu, Dingcheng, Wang, Qingxiu, Wang, Zuoren
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 03-09-2020
• Subjects: Action Potentials; Animals; Auditory Cortex - physiology; Behavior, Animal; Beta Rhythm; Discrimination, Psychological - physiology; Male; Neurons - physiology; Parietal Lobe - physiology; Rats, Sprague-Dawley; electrophysiology; phase lock; selective attention; decision making; beta oscillation
• ISSN: 1047-3211; 1460-2199
• DOI: 10.1093/cercor/bhaa125

Abstract
How does the brain selectively process signals from stimuli of different modalities? Coherent oscillations may function in coordinating communication between neuronal populations simultaneously involved in such cognitive behavior. Beta power (12–30 Hz) is implicated in top-down cognitive processes. Here we test the hypothesis that the brain increases encoding and behavioral influence of a target modality by shifting the relationship of neuronal spike phases relative to beta oscillations between primary sensory cortices and higher cortices. We simultaneously recorded neuronal spike and local field potentials in the posterior parietal cortex (PPC) and the primary auditory cortex (A1) when male rats made choices to either auditory or visual stimuli. Neuronal spikes exhibited modality-related phase locking to beta oscillations during stimulus sampling, and the phase shift between neuronal subpopulations demonstrated faster top-down signaling from PPC to A1 neurons when animals attended to auditory rather than visual stimuli. Importantly, complementary to spike timing, spike phase predicted rats’ attended-to target in single trials, which was related to the animals’ performance. Our findings support a candidate mechanism that cortices encode targets from different modalities by shifting neuronal spike phase. This work may extend our understanding of the importance of spike phase as a coding and readout mechanism.