Strain-Dependent Differences in the Specificity of Antibody Responses toward Lysozyme

Strain-Dependent Differences in the Specificity of Antibody Responses toward Lysozyme

Most mouse strains responded well to immunization with lysozyme, but only certain strains produced antibodies against a conjugate consisting of the “loop” region (residues 60–83) of lysozyme attached to a synthetic polymer. The latter strains, which did not respond to the above synthetic conjugate,...

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Bibliographic Details
Published in:The Journal of immunology (1950) Vol. 106; no. 3; pp. 862 - 864
Main Authors: Mozes, Edna, Maron, Elchanan, Arnon, Ruth, Sela, Michael
Format: Journal Article
Language:English
Published: United States Am Assoc Immnol 01-03-1971
Subjects:
Alanine
Animals
Antibodies
Antibody Formation
Antibody Specificity
Antigens
Erythrocytes - immunology
Haptens
Immunogenetics
Mice
Muramidase
Peptides
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Summary:Most mouse strains responded well to immunization with lysozyme, but only certain strains produced antibodies against a conjugate consisting of the “loop” region (residues 60–83) of lysozyme attached to a synthetic polymer. The latter strains, which did not respond to the above synthetic conjugate, were also unable to produce antibodies specific for the “loop” region when injected with intact lysozyme. The F1 hybrid between low and high responders showed an intermediate response. It appears that the immune response to the natural determinants of proteins is genetically controlled.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.106.3.862