Hexose monophosphate shunt enzymes in lung tumors from normal and glucose-6-phosphate-dehydrogenase-deficient subjects

Glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate, dehydrogenase the key enzymes of the hexose monophosphate shunt pathway, were measured in both surrounding and tumoral lung tissues from normal and G6PD-deficient subjects. A significant increase of these enzymatic activities in tumora...

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Bibliographic Details
Published in:	Oncology Vol. 45; no. 4; p. 287
Main Authors:	Dessì, S, Batetta, B, Cherchi, R, Onnis, R, Pisano, M, Pani, P
Format:	Journal Article
Language:	English
Published:	Switzerland 1988
Subjects:	Adult Aged Erythrocytes - enzymology Female Glucosephosphate Dehydrogenase - analysis Glucosephosphate Dehydrogenase Deficiency - enzymology Humans Lung Neoplasms - enzymology Male Middle Aged Pentose Phosphate Pathway Phosphogluconate Dehydrogenase - analysis
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Summary:	Glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate, dehydrogenase the key enzymes of the hexose monophosphate shunt pathway, were measured in both surrounding and tumoral lung tissues from normal and G6PD-deficient subjects. A significant increase of these enzymatic activities in tumoral tissue was found not only in G6PD-normal patients, but also in G6PD-deficient patients with very low or nonmeasurable G6PD activity in both erythrocytes and normal lung tissue.
ISSN:	0030-2414
DOI:	10.1159/000226624