Maturation-related differences in regional circulatory effects of dopamine infusion in swine

• Published in: Developmental pharmacology and therapeutics Vol. 6; no. 1; p. 9
• Main Authors: Gootman, N, Buckley, B J, Gootman, P M, Griswold, P G, Mele, J D, Nudel, D B
• Format: Journal Article
• Language: English
• Published: Switzerland 1983
• Subjects: Aging; Animals; Dopamine - pharmacology; Electrocardiography; Heart Rate - drug effects; Hemodynamics - drug effects; Regional Blood Flow - drug effects; Splanchnic Circulation - drug effects; Swine; Vasodilation - drug effects
• ISSN: 0379-8305
• DOI: 10.1159/000457273

The cardiovascular effects of dopamine (DPA) infusions were evaluated in developing swine, less than or equal to 1 day, 2 weeks, and 2 months of age, anesthetized with halothane in 50% N2O and O2. DPA was given by intravenous infusion in randomized doses of 2, 5, 10 and 20 micrograms/kg/min for 10 min. Depressor responses and bradycardia were observed during 2 micrograms/kg/min in 2-week-olds and during 2, 5 and 10 micrograms/kg/min in 2-month-olds. During infusion of 20 micrograms/kg/min, DPA pressor responses were observed in animals less than or equal to 2 weeks of age; in addition, tachycardia occurred in 1-day-old swine. Renal resistance decreased during infusion of 2 micrograms/kg/min in all swine. It increased during 10 and 20 micrograms/kg/min in the 1-day and 2-week groups, but not in the 2-month group. Mesenteric resistance decreased during infusion of 2, 5 and 10 micrograms/kg/min in less than or equal to 2-week-olds and at all doses in 2-month-olds. Following combined alpha- and beta-adrenergic receptor blockade, infusion of 20 micrograms/kg/min DPA inhibited renal vasoconstriction in most animals and elicited mesenteric vasodilation in all. The results indicate that dopaminergic responses undergo a postnatal maturation which has a different time course for different regional circulations.