Cingulate cortex in pre-MCI cognition

• Published in: Handbook of clinical neurology Vol. 166; p. 281
• Main Authors: Sambuchi, Nathalie, Geda, Yonas Endale, Michel, Bernard François
• Format: Journal Article
• Language: English
• Published: Netherlands 2019
• Subjects: Alzheimer Disease - physiopathology; Cognitive Dysfunction - physiopathology; Gyrus Cinguli - physiopathology; Humans; Prodromal Symptoms; DTI; Cognition; MRI; Cingulate gyrus; Cingulum bundle; Pre-MCI
• ISSN: 0072-9752
• DOI: 10.1016/B978-0-444-64196-0.00015-7

Studies of Alzheimer's disease over the years have focused on the prodromal stage, or mild cognitive impairment (MCI), in order to understand its evolution and to diagnose this pathology early. More recently, research has focused on an even earlier stage (pre-MCI) characterized in particular by a cognitive complaint. The purpose of this chapter is, first, to describe the different concepts defining pre-MCI, which refers to cognitive or memory complaint, and to define this concept based on biologic markers (abnormal proteins and neuroimaging). In the second part of the chapter, we describe the cognitive performance of these subjects (pre-MCI), and, finally, in the third part we describe the correlations linking cognitive performance of pre-MCI subjects to cingulate cortex, cingulate gyrus, and cingulum bundle.