OPTICAL COHERENCE TOMOGRAPHY FEATURES IN IDIOPATHIC NONINFECTIOUS INTERMEDIATE, POSTERIOR, OR PANUVEITIS

• Published in: Retina (Philadelphia, Pa.) Vol. 42; no. 11; pp. 2143 - 2149
• Main Authors: Felfeli, Tina, Eshtiaghi, Arshia, Tai, Felicia, Batawi, Hatim, Rhee, Jess, Kryshtalskyj, Michael, Dzulynsky, Kira, Bakshi, Nupura K., Derzko-Dzulynsky, Larissa A.
• Format: Journal Article
• Language: English
• Published: Retina 01-11-2022
• ISSN: 0275-004X; 1539-2864
• DOI: 10.1097/IAE.0000000000003572

Purpose:
To characterize optical coherence tomography features in patients with idiopathic intermediate, posterior, or panuveitis.
Methods:
This is a retrospective case series of all consecutive cases of idiopathic intermediate, posterior, or panuveitis at four tertiary care centres between 2010 and 2021.
Results:
A total of 94 eyes (55 patients) were followed for an average duration of 29.8 (SD 21) months. The median central macular thickness was 284
µ
m at baseline and 267
µ
m at last follow-up. At baseline and last follow-up, respectively, 24% and 20% of uveitic eyes had intraretinal fluid, 12% and 1% subretinal fluid, and 43% and 54% epiretinal membrane. In addition, ellipsoid zone abnormalities on en-face were noted in 34% and 19% of cases at baseline and last follow-up, respectively. The baseline median visual acuity was significantly lower among cases with ellipsoid zone en-face slab abnormalities compared with those without (0.2 logarithm of minimum angle of resolution [interquartile range: 0–0.6] vs. 0.1 logarithm of minimum angle of resolution [interquartile range: 0–0.3],
P
= 0.0051).
Conclusion:
With initiation of treatment, the central macular thickness, intraretinal fluid, subretinal fluid, and ellipsoid zone en-face abnormalities improved over time, whereas the number of cases with epiretinal membrane increased among eyes with idiopathic intermediate, posterior, and panuveitis. Presence of ellipsoid zone en-face abnormalities at presentation may be associated with worse visual acuity.