Distribution and fate of DCX/PSA-NCAM expressing cells in the adult mammalian cortex： A local reservoir for adult cortical neuroplasticity

• Published in: Frontiers in biology Vol. 11; no. 3; pp. 193 - 213
• Main Authors: Konig, Richard, Benedetti, Bruno, Rotheneichner, Peter, Sullivan, Anna O', Kreutzer, Christina, Belles, Maria, Nacher, Juan, Weiger, Thomas M, Aigner, Ludwig, Couillard-Despres, Sebastien
• Format: Journal Article
• Language: English
• Published: Beijing Higher Education Press 01-06-2016
• Subjects: Biochemistry; Biomedical and Life Sciences; Cell Biology; Developmental Biology; GABA能神经元; Genetics and Population Dynamics; Life Sciences; Neurobiology; Proteomics; Review; 可塑性; 大脑皮层; 成人; 成年哺乳动物; 皮质层; 皮质神经元; 神经细胞粘附分子; piriform cortex; neurogenesis; plasticity; doublecortin; aging; cognition
• ISSN: 1674-7984; 1674-7992
• DOI: 10.1007/s11515-016-1403-5

Abstract The expression of early developmental markers such as doublecortin （DCX） and the polysialylated-neural cell adhesion molecule （PSA-NCAMIp has been used to identify immature neurons within canonical neurogenic niches. Additionally, DCX/PSA-NCAM ＋ immature neurons reside in cortical layer II of the paleocortex and in the paleo- and entorhinal cortex of mice and rats, respectively. These cells are also found in the neocortex of guinea pigs, rabbits, some afrotherian mammals, cats, dogs, non-human primates, and humans. The population of cortical DCX/PSA-NCAM ＋ immature neurons is generated prenatally as conclusively demonstrated in mice, rats, and guinea pigs. Thus, the majority of these cells do not appear to be the product of adult proliferative events. The immature neurons in cortical layer II are most abundant in the corlLices of young individuals, while very few DCX/PSA-NCAM ＋ cortical neurons can be detected in aged mammals. Maturation of DCX/PSA-NCAM ＋ cells into glutamatergic and GABAergic neurons has been proposed as an explanation for the age-dependent reduction in their population over time. In this review, we compile the recent information regarding the age-related decrease in the number of cortical DCX/PSA-NCAM ＋ neurons. We compare the distribution and fates of DCX/PSA-NCAM ＋ neurons among mammalian species and speculate their impact on cognitive function. To respond to the diversity of adult neurogenesis research produced over the last number of decades, we close this review by discussing the use and precision of the term ＂adult non-canonical neurogenesis.＂