Double CD4/CD8-Positive, Nonpoikilodermic Mycosis Fungoides Expressing CD56 in a Young Man

We report a case of mycosis fungoides (MF) in an 18-year-old man whose neoplastic T cells expressed CD4, CD8, and CD56, with no evidence of TCR-delta or Epstein–Barr virus (EBER) expression. Clinically, neither hypopigmentation nor hyperpigmentation nor poikilodermatous skin lesions were present, an...

Full description

Saved in:

Bibliographic Details
Published in:	The American journal of dermatopathology Vol. 44; no. 12; pp. 936 - 939
Main Authors:	Santonja, Carlos, Sánchez-García, Francisco-Javier, Rodríguez-Rodríguez, Rosa-Nieves, Manso, Rebeca, Requena, Luis, Gil-Mateo, María del Pino, Rodríguez-Pinilla, Socorro-María
Format:	Journal Article
Language:	English
Published:	The American Journal of Dermatopathology 01-12-2022
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	We report a case of mycosis fungoides (MF) in an 18-year-old man whose neoplastic T cells expressed CD4, CD8, and CD56, with no evidence of TCR-delta or Epstein–Barr virus (EBER) expression. Clinically, neither hypopigmentation nor hyperpigmentation nor poikilodermatous skin lesions were present, and the lesions subsided with oral corticoids and retinoids and environmental solar ultraviolet exposure. Our case represents the oldest patient reported so far with nonpoikilodermatous, CD8/CD56 MF and adds to the phenotypic diversity of MF in the pediatric population. This distinct phenotype does not seem to be linked to a more aggressive course than the classic CD-4 positive one.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0193-1091 1533-0311
DOI:	10.1097/DAD.0000000000002259