In-vivo analysis of iron-gold composite nanoparticles as potential exogenous contrast agents for magnetomotive optical coherence tomography (MMOCT)

• Published in: Journal of magnetism and magnetic materials Vol. 514; p. 167211
• Main Authors: Indoliya, Abhishek, Dhar, Dhruba, Mohan, Muktesh, Poddar, Raju
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 15-11-2020; Elsevier BV
• Subjects: Contrast agents; Frequency modulation; Gold; Image contrast; Iron; Iron-gold composite; Magnetic nanoparticles; Magnetomotive optical coherence tomography; Nano-scale displacement; Nanoparticles; Optical Coherence Tomography; Resonant frequencies; Time dependence; Tomography; Magnetomotive optical coherence tomography; Contrast agents; Iron-gold composite; Nano-scale displacement; Frequency modulation; Magnetic nanoparticles
• ISSN: 0304-8853; 1873-4766
• DOI: 10.1016/j.jmmm.2020.167211

•A new iron-gold (Fe-Au) composite magnetic nanoparticles (MNPs) were reported.•A new robust imaging method Magnetomotive Optical Coherence Tomography (MMOCT) was developed.•High contrast and specific background subtracted MMOCT images was generated.•The system was validated with in-vivo imaging of mice model.•A penetration dynamic of MNPs in tissue was also demonstrated.
Magnetomotive optical coherence tomography (MMOCT) is a functional modification of conventional optical coherence tomography (OCT). It utilizes the nano-scale displacement embedded magnetic nanoparticles (MNPs) and subsequent amplitude and phase changes in OCT interferogram scattered from samples. We report a new robust method for ‘phase-lock-in’ detection of MMOCT signals and subsequent imaging. We validated this method utilizing iron-gold (Fe-Au) composite nanoparticles as an exogenous contrast agent for MMOCT. High contrast and specific background-subtracted images was generated for Fe-Au MNPs targeted samples. MMOCT with MNPs imaging systems was corroborated with tissue phantoms and in-vivo swiss albino mice model with modulating external magnetic field (resonant frequency of 30 Hz). A time-dependent dynamics study of diffusion for MNPs inside the tissue of mice as a function of time and depth is also reported.