Topical Antiedematogenic Activity of the Essential Oil of Psidium brownianum Mart. (OEPB) in Murine Ear Edema Models

• Published in: Chemistry & biodiversity Vol. 21; no. 4; pp. e202400187 - n/a
• Main Authors: Souza Sampaio, Renata, Brito Pereira Bezerra Martins, Anita Oliveira, Santos da Silva, Lucas Yure, Torres Pessoa, Dra.Renata, Ribeiro‐Filho, Jaime, Araújo Delmondes, Gyllyandeson, Bezerra Felipe, Cícero Francisco, Alencar de Menezes, Irwin Rose, Kerntopf, Marta Regina
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01-04-2024
• Subjects: Animal models; Antiedematogenic; Arachidonic acid; Capsaicin; Edema; Essential oil; Essential oils; Histamine; Inflammation; Inflammatory models; Metabolites; Oils & fats; Pain perception; Phenols; Psidium; Psidium brownianum; Secondary metabolites; Inflammatory models; Essential oil; Psidium brownianum; Antiedematogenic
• ISSN: 1612-1872; 1612-1880
• DOI: 10.1002/cbdv.202400187

Psidium brownianum Mart is reported in the literature by antinociceptive and antioxidant activities, indicating that this species′ secondary metabolites might be used to control inflammatory processes. The present study aimed to characterize the topical antiedematogenic activity of the essential oil of Psidium brownianum Mart. (OEPB) in ear edema models by different inflammatory agents. Female Swiss mice (25–35 g) and Wistar albino rats (200–300 g) were used throughout tests (n=6/group) on acute or chronic edema models induced by single and multiple topical applications. The OEPB is administered topically pure or at a concentration of 100 or 200 mg/mL. The antiedematogenic mechanism of OEPB was analyzed by administering capsaicin, arachidonic acid, histamine, and phenol at the best effective dose (200 mg/mL). The results showed a significant reduction of edema‐induced single (28.87 %) and multiple (50.13 %) applications of croton oil compared to the negative control group. Regarding potential mechanisms of action, OEPB (200 mg/mL) inhibited the development of edema triggered by capsaicin (29.95 %), arachidonic acid (22.66 %), phenol (23.35 %), and histamine (75.46 %), suggesting an interference with the histaminergic pathway. These results indicate that OEPB presents a topical antiedematogenic effect in acute and chronic murine models, possibly interfering with inflammatory pathways triggered by mediators such as histamine.