A literature review on pharmacological aspects, docking studies, and synthetic approaches of quinazoline and quinazolinone derivatives

• Published in: Archiv der Pharmazie (Weinheim) Vol. 357; no. 8; pp. e2400057 - n/a
• Main Authors: Ghoneim, Mohammed M., Abdelgawad, Mohamed A., Elkanzi, Nadia A. A., Parambi, Della Grace Thomas, Alsalahat, Izzeddin, Farouk, Amr, Bakr, Rania B.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01-08-2024
• Subjects: anticancer; antimicrobial; anti‐inflammatory; quinazoline; quinazolinone; quinazolinone; antimicrobial; quinazoline; anti‐inflammatory; anticancer
• ISSN: 0365-6233; 1521-4184; 1521-4184
• DOI: 10.1002/ardp.202400057

Quinazoline and quinazolinone derivatives piqued medicinal chemistry interest in developing novel drug candidates owing to their pharmacological potential. They are important chemicals for the synthesis of a variety of physiologically significant and pharmacologically useful molecules. Quinazoline and quinazolinone derivatives have anticancer, anti‐inflammatory, antidiabetic, anticonvulsant, antiviral, and antimicrobial potential. The increased understanding of quinazoline and quinazolinone derivatives in biological activities provides opportunities for new medicinal products. The present review focuses on novel advances in the synthesis of these important scaffolds and other medicinal aspects involving drug design, structure–activity relationship, and action mechanisms of quinazoline and quinazolinone derivatives to help in the development of new quinazoline and quinazolinone derivatives.
This review focuses on new advances in the synthesis of quinazoline and quinazolinone derivatives and their pharmacological aspects as antitubercular, anticancer, anti‐inflammatory, antimicrobial, antidiabetic, and anticonvulsant agents, to assist in the development of these new privileged scaffolds.