Adjunctive low-dose doxycycline therapy effect on clinical parameters and gingival crevicular fluid tissue plasminogen activator levels in chronic periodontitis

• Published in: Inflammation research Vol. 55; no. 12; pp. 550 - 558
• Main Authors: Emingil, G, Gürkan, A, Atilla, G, Berdeli, A, Cinarcik, S
• Format: Journal Article
• Language: English
• Published: Switzerland Springer Nature B.V 01-12-2006
• Subjects: Chronic Periodontitis - therapy; Dental Scaling; Doxycycline - administration & dosage; Gingival Crevicular Fluid; Humans; Tissue Plasminogen Activator
• ISSN: 1023-3830; 1420-908X
• DOI: 10.1007/s00011-006-6074-2

The present study examined effectiveness of low-dose doxycycline (LDD) in combination with nonsurgical therapy on gingival crevicular fluid (GCF) tissue plasminogen activator (t-PA) levels and clinical parameters in chronic periodontitis (CP) a over 12-month period.
GCF samples were collected, probing depth (PD), clinical attachment level (CAL), gingival index (GI) and plaque index were recorded at baseline, 3, 6, 9 and 12 months. CP patients (n = 65) were randomized to LDD or placebo groups. LDD group received LDD (20 mg) b.i.d for 3-months plus and root planing (SRP), while placebo group was given placebo capsules b.i.d for 3-months plus SRP. GCF t-PA levels were determined by ELISA. Friedman, Wilcoxon and Mann-Whitney test was used for statistical analysis.
Significant improvement was observed in all clinical parameters in both groups over 12-month period (p < 0.01). LDD group had lower PD, CAL and GI scores than placebo group at 6, 9 and 12-months (p < 0.05). GCF t-PA levels reduced in both groups over 12-month period (p < 0.01). LDD group had lower GCF t-PA levels than placebo group at 6 and 9-months (p < 0.05).
These results provide additional information about usefulness of LDD therapy as an adjunct to nonsurgical therapy in long-term management of periodontitis.