Increased glucose disappearance rate after short-term clofibrate administration in normal subjects and in patients with chemical diabetes

Following seven days clofibrate administration, the glucose disappearance rate during an intravenous glucose tolerance test was significantly increased in 6 normal subjects and in 11 patients with chemical diabetes. Both the acute and the total insulin secretory response were unchanged. Though fasti...

Full description

Saved in:

Bibliographic Details
Published in:	Hormone and metabolic research Vol. 10; no. 1; p. 4
Main Authors:	Ferrari, C, Testori, G P, Bertazzoni, A, Romussi, M, Caldara, R, Frezzati, S
Format:	Journal Article
Language:	English
Published:	Germany 01-01-1978
Subjects:	Blood Glucose - metabolism Cholesterol - blood Clofibrate Diabetes Mellitus - blood Fatty Acids, Nonesterified - blood Humans Insulin - blood Middle Aged Triglycerides - blood
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Following seven days clofibrate administration, the glucose disappearance rate during an intravenous glucose tolerance test was significantly increased in 6 normal subjects and in 11 patients with chemical diabetes. Both the acute and the total insulin secretory response were unchanged. Though fasting serum levels of free fatty acids, triglycerides, and cholesterol were significantly lowered by treatment, no correlation was found between the decrease in serum lipids and the increase in glucose disappearance rate. It is suggested and clofibrate improves glucose utilization by reducing insulin resistance irrespective of its effects on serum lipids concentration.
ISSN:	0018-5043
DOI:	10.1055/s-0028-1093469