Anaemia associated with canine lymphoma

• Published in: Comparative Haematology International Vol. 8; no. 1; pp. 1 - 6
• Main Authors: Lucroy, M. D., Christopher, M. M., Kraegel, S. A., Simonson, E. R., Madewell, B. R.
• Format: Journal Article
• Language: English
• Published: London Springer Nature B.V 01-01-1998
• Subjects: Anemia; Bone marrow; Dogs; Iron
• ISSN: 0938-7714; 1618-5641; 1618-565X
• DOI: 10.1007/BF02628097

Dogs with previously untreated multicentric lymphoma were evaluated for the presence of the anaemia of chronic disease (ACD). Specimens were collected for histopathology, haematology, serum biochemistry, direct antiglobulin test (DAT), total serum iron concentration (TSI), total iron binding capacity (TIBC), bone marrow cytology, bone marrow iron determination and serum erythropoietin concentration (EPO). Thirty-five dogs were included in the study. The haematocrit of anaemic dogs (n = 15, mean ± standard error: 0.316 ± 0.00841/1, reference range 0.37-0.55l/l) was significantly (p<0.0001) less than non-anaemic dogs (n = 20, mean 0.446 ± 0.0128 1/l). Anaemic dogs had normal TSI (mean 23 ± 3.1μmol/l, reference range 6-26μmol/l, normal TIBC (mean 61 ± 2.70μmol/l, reference range 50-69μmol/l, increased serum ferritin concentration (mean 1104 ± 192μg/l, reference range 80-800μg/l, and normal serum EPO (mean 14.6 ±1.88 U/1, reference range 5-15 U/l). Non-anaemic dogs had slightly increased TSI (mean 30 ± 2.8μmol/l), normal TIBC (mean 60 ± 4.3μmol/l), increased serum ferritin concentration (mean 1543 ± 302μg/l, and normal serum EPO (mean 14.5 ± 1.64 U/l,n = 23). These values were not significantly different between groups (p>0.1). Bone marrow iron stores were normal to increased in all dogs. These results do not support ACD as the cause of anaemia in dogs with lymphoma.[PUBLICATION ABSTRACT]