Correlation between Yersinia enterocolitica and type I collagen reactivity in patients with arthropathies

• Published in: Rheumatology international Vol. 27; no. 7; pp. 613 - 620
• Main Authors: Lacoste, María G, Tamashiro, Héctor, Correa, Silvia G, de Guzmán, Ana M S, Di Genaro, María S
• Format: Journal Article
• Language: English
• Published: Germany Springer Nature B.V 01-05-2007
• Subjects: Adult; Aged; Antibodies, Bacterial - blood; Arthritis - immunology; Arthritis - microbiology; Arthritis, Reactive - immunology; Arthritis, Reactive - microbiology; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - immunology; Bacteria; Blotting, Western; Collagen; Collagen Type I - immunology; Collagen Type II - immunology; Enzyme-Linked Immunosorbent Assay; Epitopes; Female; Humans; Lipopolysaccharides - immunology; Male; Middle Aged; Osteoarthritis - complications; Osteoarthritis - immunology; Polymerase Chain Reaction; Spondylarthropathies - complications; Spondylarthropathies - immunology; Synovial Fluid - immunology; Yersinia enterocolitica - genetics; Yersinia enterocolitica - immunology; Yersinia Infections - complications; Yersinia Infections - immunology
• ISSN: 0172-8172; 1437-160X
• DOI: 10.1007/s00296-006-0274-5

We investigated the association with Yersinia infection in patients with arthropathies in our region. To assess the reactivity to articular antigens, the correlation of anti-Yersinia with anti-type I and type II collagen antibodies was studied. Sera from 124 patients with musculoskeletal symptoms, and 47 synovial fluids (SF) from patients with rheumatoid arthritis (RA), spondyloarthopathies (SpA) or osteoarthritis (OA) were examined. Immunoglobulins against Yersinia enterocolitica, type I and type II collagens were determined by enzyme-linked immunosorbent assay. Immunoglobulin (Ig) A to Yersinia lipopolysaccharide (LPS) was present in 13/124 sera (10%) and 3/47 SF (6%). By Western blot, IgA to Yersinia outer proteins (Yops) was found in 14/124 sera (11%) and 2/47 SF (4%). Yersinia DNA from SF was not amplified by polymerase chain reaction. We found a significant correlation with anti-collagen type I but not type II antibodies. These results suggest different reactivity to articular collagen in patients with Yersinia antibodies.