Improper Proteostasis: Can It Serve as Biomarkers for Neurodegenerative Diseases?

• Published in: Molecular neurobiology Vol. 59; no. 6; pp. 3382 - 3401
• Main Authors: Dubey, Ankur Rakesh, Patwa, Som Mohanlal, Kinger, Sumit, Jagtap, Yuvraj Anandrao, Kumar, Prashant, Singh, Sarika, Dhiman, Rohan, Jha, Hem Chandra, Mishra, Amit
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-06-2022; Springer Nature B.V
• Subjects: Biomarkers; Biomedical and Life Sciences; Biomedicine; Cell Biology; Nervous system; Neurobiology; Neurodegeneration; Neurodegenerative diseases; Neurology; Neurosciences; Protein folding; Proteins; Quality control; Neural diseases; Biomarker; Proteostasis; Neurodegeneration; UPS; Chaperones; Exosomes; Autophagy
• ISSN: 0893-7648; 1559-1182
• DOI: 10.1007/s12035-022-02775-w

Cells synthesize new proteins after multiple molecular decisions. Damage of existing proteins, accumulation of abnormal proteins, and basic requirement of new proteins trigger protein quality control (PQC)-based alternative strategies to cope against proteostasis imbalance. Accumulation of misfolded proteins is linked with various neurodegenerative disorders. However, how deregulated components of this quality control system and their lack of general mechanism-based long-term changes can serve as biomarkers for neurodegeneration remains largely unexplored. Here, our article summarizes the chief findings, which may facilitate the search of novel and relevant proteostasis mechanism-based biomarkers associated with neuronal disorders. Understanding the abnormalities of PQC coupled molecules as possible biomarkers can help to determine neuronal fate and their contribution to the aetiology of several nervous system disorders.