Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography
To investigate whether focal high maximum standardized uptake value (SUVmax) determined by 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) imaging is correlated with proliferation index in the colorectal region. SUVmax values of 31 colorectal neoplasms that we...
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| Published in: | Turkish journal of medical sciences Vol. 46; no. 4; pp. 1182 - 1187 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Turkey
01-01-2016
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| Abstract | To investigate whether focal high maximum standardized uptake value (SUVmax) determined by 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) imaging is correlated with proliferation index in the colorectal region.
SUVmax values of 31 colorectal neoplasms that were incidentally detected during PET-CT examination were compared to dysplasia degree, histopathologic diagnosis, and immunohistochemical expression of the Ki-67 proliferation marker.
Statistically significant correlations were found between SUVmax and Ki-67 proliferation index, dysplasia degree, and histopathologic diagnosis. Median SUVmax value was found to be significantly higher in high-risk lesions than low-risk lesions.
The Ki-67 proliferation index is an indicator of SUVmax in colorectal tract. SUVmax values can predict malignancy and prognosis in this region. Colonoscopy and biopsy should always be performed whenever a focal high FDG uptake is determined incidentally in a patient. |
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| AbstractList | To investigate whether focal high maximum standardized uptake value (SUVmax) determined by 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) imaging is correlated with proliferation index in the colorectal region.
SUVmax values of 31 colorectal neoplasms that were incidentally detected during PET-CT examination were compared to dysplasia degree, histopathologic diagnosis, and immunohistochemical expression of the Ki-67 proliferation marker.
Statistically significant correlations were found between SUVmax and Ki-67 proliferation index, dysplasia degree, and histopathologic diagnosis. Median SUVmax value was found to be significantly higher in high-risk lesions than low-risk lesions.
The Ki-67 proliferation index is an indicator of SUVmax in colorectal tract. SUVmax values can predict malignancy and prognosis in this region. Colonoscopy and biopsy should always be performed whenever a focal high FDG uptake is determined incidentally in a patient. BACKGROUND/AIMTo investigate whether focal high maximum standardized uptake value (SUVmax) determined by 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) imaging is correlated with proliferation index in the colorectal region.MATERIALS AND METHODSSUVmax values of 31 colorectal neoplasms that were incidentally detected during PET-CT examination were compared to dysplasia degree, histopathologic diagnosis, and immunohistochemical expression of the Ki-67 proliferation marker.RESULTSStatistically significant correlations were found between SUVmax and Ki-67 proliferation index, dysplasia degree, and histopathologic diagnosis. Median SUVmax value was found to be significantly higher in high-risk lesions than low-risk lesions.CONCLUSIONThe Ki-67 proliferation index is an indicator of SUVmax in colorectal tract. SUVmax values can predict malignancy and prognosis in this region. Colonoscopy and biopsy should always be performed whenever a focal high FDG uptake is determined incidentally in a patient. |
| Author | Yeniova, Abdullah Özgür Güreşci, Servet Şimşek, Gülçin Gökçek, Atila Özmen, Özlem Tatci, Ebru Uzman, Metin |
| Author_xml | – sequence: 1 givenname: Servet surname: Güreşci fullname: Güreşci, Servet organization: Department of Pathology, Keçiören Training and Research Hospital, Ankara, Turkey – sequence: 2 givenname: Özlem surname: Özmen fullname: Özmen, Özlem organization: Department of Nuclear Medicine, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey – sequence: 3 givenname: Metin surname: Uzman fullname: Uzman, Metin organization: Department of Gastroenterology, Keçiören Training and Research Hospital, Ankara, Turkey – sequence: 4 givenname: Gülçin surname: Şimşek fullname: Şimşek, Gülçin organization: Department of Pathology, Keçiören Training and Research Hospital, Ankara, Turkey – sequence: 5 givenname: Ebru surname: Tatci fullname: Tatci, Ebru organization: Department of Nuclear Medicine, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey – sequence: 6 givenname: Atila surname: Gökçek fullname: Gökçek, Atila organization: Department of Radiology, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Ankara, Turkey – sequence: 7 givenname: Abdullah Özgür surname: Yeniova fullname: Yeniova, Abdullah Özgür organization: Department of Gastroenterology, Keçiören Training and Research Hospital, Ankara, Turkey |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27513423$$D View this record in MEDLINE/PubMed |
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| Snippet | To investigate whether focal high maximum standardized uptake value (SUVmax) determined by 18-fluorodeoxyglucose (FDG) positron emission tomography... BACKGROUND/AIMTo investigate whether focal high maximum standardized uptake value (SUVmax) determined by 18-fluorodeoxyglucose (FDG) positron emission... |
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| SubjectTerms | Cell Proliferation Colorectal Neoplasms Fluorodeoxyglucose F18 Humans Multimodal Imaging Positron Emission Tomography Computed Tomography Positron-Emission Tomography Radiopharmaceuticals Retrospective Studies Tomography, X-Ray Computed |
| Title | Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography |
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