Correlation of Ki-67 proliferation index and 18-fluorodeoxyglucose uptake in colorectal incidental lesions detected by positron emission tomography-computed tomography

• Published in: Turkish journal of medical sciences Vol. 46; no. 4; pp. 1182 - 1187
• Main Authors: Güreşci, Servet, Özmen, Özlem, Uzman, Metin, Şimşek, Gülçin, Tatci, Ebru, Gökçek, Atila, Yeniova, Abdullah Özgür
• Format: Journal Article
• Language: English
• Published: Turkey 01-01-2016
• Subjects: Cell Proliferation; Colorectal Neoplasms; Fluorodeoxyglucose F18; Humans; Multimodal Imaging; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radiopharmaceuticals; Retrospective Studies; Tomography, X-Ray Computed; positron emission tomography; Ki-67 antigen; Colorectal neoplasm
• ISSN: 1300-0144; 1303-6165
• DOI: 10.3906/sag-1410-24

To investigate whether focal high maximum standardized uptake value (SUVmax) determined by 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) imaging is correlated with proliferation index in the colorectal region.
SUVmax values of 31 colorectal neoplasms that were incidentally detected during PET-CT examination were compared to dysplasia degree, histopathologic diagnosis, and immunohistochemical expression of the Ki-67 proliferation marker.
Statistically significant correlations were found between SUVmax and Ki-67 proliferation index, dysplasia degree, and histopathologic diagnosis. Median SUVmax value was found to be significantly higher in high-risk lesions than low-risk lesions.
The Ki-67 proliferation index is an indicator of SUVmax in colorectal tract. SUVmax values can predict malignancy and prognosis in this region. Colonoscopy and biopsy should always be performed whenever a focal high FDG uptake is determined incidentally in a patient.