Evaluation of the effectiveness of mother milk exosomes in the experimental corrosive esophagitis model

• Published in: Pediatric surgery international Vol. 40; no. 1; p. 118
• Main Authors: Bozoğlu, Sema Tural, Cömert, Hatice Sonay Yalçın, Şalcı, Gül, Alver, Ahmet, Saygın, İsmail, Sağlam, Neslihan, Erdem, Şeniz, İmamoğlu, Mustafa, Sarıhan, Haluk
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 02-05-2024; Springer Nature B.V
• Subjects: Animals; Breastfeeding & lactation; Burns, Chemical - therapy; Caustics - toxicity; Disease Models, Animal; Esophagitis - chemically induced; Esophagitis - pathology; Esophagus; Esophagus - pathology; Exosomes; Female; Inflammation; Male; Medicine; Medicine & Public Health; Metadata; Milk, Human; Original Article; Pediatric Surgery; Pediatrics; Rats; Sodium Hydroxide - toxicity; Surgery; Inflammation; Corrosive esophagus; Mother milk exosomes; Fibrosis
• ISSN: 1437-9813; 0179-0358; 1437-9813
• DOI: 10.1007/s00383-024-05701-4

Purpose
We aimed to examine the effectiveness of mother milk exosomes in treating corrosive esophageal burns.
Materials and methods
32 rats were separated into four equal groups and weighed individually before the procedure. A corrosive esophageal burn model was created with 12.5% sodium hydroxide by a 3F Fogarty catheter. Group 1 did not apply any process or treatment, Group 2 was burned, and no treatment was performed. Group 3 was burned, and then 0.5 cc/day of mother milk exosome extract was given. Group 4 was not applied any process, and 0.5 cc/day mother milk exosome extract was given. All rats were weighed again and sacrificed. Biopsy samples were sent to the pathology laboratory for histopathological examination (in terms of inflammation, fibrosis, and necrosis).Kindly check and confrm all email ids.The e-mail addresses and affiliation of all authors were checked. Affiliation departments are as stated on the title page. There is no change.
Results
A significant difference was found in the results of inflammation and fibrosis. There was a meaningful difference in fibrosis between the 2nd and 3rd groups. There was weight gain in groups 1, 3 and 4. Statistical evaluations for each group were significant.
Conclusion
It was observed that breast milk exosomes may be effective in inflammation and fibrosis formation in treating corrosive esophageal burns. This suggested that breast milk exosomes reduce stricture formation due to esophageal corrosion.Please confirm if the author names are presented accurately and in the correct sequence (given name, middle name/initial, family name). Author 1 Given name: [specify authors given name] Last name [specify authors last name]. Also, kindly confirm the details in the metadata are correct.The names and affiliation of all authors were checked. Affiliation departments are as stated on the title page. There is no change. Also we confirm the details in the metadata.