Topographical distribution and prevalence of basal duct–like recess sign in a cohort of Papillary Craniopharyngioma—novel findings and implications

• Published in: Neuroradiology Vol. 66; no. 6; pp. 947 - 953
• Main Authors: Malik, Prateek, Chen, Yingming Amy, Mathew, Benjamin Barsouma, Munoz, David G., Selvi, Bernice Thamarai, Vanjare, Harshad Arvind, Jasper, Anitha, Mannam, Pavithra, Bharatha, Aditya, Mathur, Shobhit
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-06-2024; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Craniopharyngioma - diagnostic imaging; Diagnostic Neuroradiology; Female; Humans; Imaging; Magnetic Resonance Imaging - methods; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasia; Neurology; Neuroradiology; Neurosciences; Neurosurgery; Origins; Pituitary; Pituitary Neoplasms - diagnostic imaging; Prevalence; Radiology; Retrospective Studies; Sensitivity and Specificity; Third Ventricle - diagnostic imaging; Third Ventricle - pathology; Topography; Tumors; Papillary craniopharyngioma; CNS tumors; Duct-like recess; Pituitary; Sella
• ISSN: 0028-3940; 1432-1920
• DOI: 10.1007/s00234-024-03355-6

Purpose
Basal duct-like recess (DR) sign serves as a specific marker of papillary craniopharyngiomas (PCPs) of the strictly third-ventricular (3 V) topography. Origins of this sign are poorly understood with limited validation in external cohorts.
Methods
In this retrospective study, MRIs of pathologically proven PCPs were reviewed and evaluated for tumor topography, DR sign prevalence, and morphological subtypes.
Results
Twenty-three cases with 24 MRIs satisfied our inclusion criteria. Median age was 44.5 years with a predominant male distribution (M/F ratio 4.7:1). Overall, strictly 3 V was the commonest tumor topography (8/24, 33.3%), and tumors were most commonly solid-cystic (10/24, 41.7%). The prevalence of DR sign was 21.7% (5/23 cases), all with strictly 3 V topography and with a predominantly solid consistency. The sensitivity, specificity and positive and negative predictive value of the DR sign for strict 3 V topography was 62.5%, 100%, 100% and 84.2% respectively. New pertinent findings associated with the DR sign were observed in our cohort. This included development of the cleft-like variant of DR sign after a 9-year follow-up initially absent at baseline imaging. Additionally, cystic dilatation of the basal tumor cleft at the pituitary stalk-tumor junction and presence of a vascular structure overlapping the DR sign were noted. Relevant mechanisms, hypotheses, and implications were explored.
Conclusion
We confirm the DR sign as a highly specific marker of the strictly 3 V topography in PCPs. While embryological and molecular factors remain pertinent in understanding origins of the DR sign, non-embryological mechanisms may play a role in development of the cleft-like variant.