Immunological and Haematological Relevance of Helminths and Mycobacterium tuberculosis Complex Coinfection among Newly Diagnosed Pulmonary Tuberculosis Patients from Bobo-Dioulasso, Burkina Faso

• Published in: Biomedicines Vol. 12; no. 7; p. 1472
• Main Authors: Djibougou, Diakourga Arthur, Mensah, Gloria Ivy, Kaboré, Achille, Toé, Inoussa, Sawadogo, Leon Tinnoga, Lompo, Palpouguini Felix, Kone, Amariane M M, Hien, Hervé, Meda, Clement Ziemlé, Combary, Adjima, Bonfoh, Bassirou, Addo, Kennedy Kwasi, Belem, Adrien Marie-Gaston, Dabiré, Roch Konbobr, Hoffmann, Jonathan, Perreau, Matthieu, Diagbouga, Potiandi Serge
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03-07-2024
• Subjects: CD4 antigen; CD4 T cells; CD4:CD8 ratio; CD8 antigen; Cytokines; Health care; Helminthiasis; Hematology; immune–haematological parameters; Immunology; Infections; Lymphocytes; Lymphocytes T; Lymphopenia; M. tuberculosis complex and helminth coinfection; Medical tests; Monocytosis; Mycobacterium tuberculosis; Parasites; Public health; Reagents; Statistical analysis; Thrombocytosis; Tuberculosis; Urine; United States > US; Burkina Faso; CD4 T cells; CD4:CD8 ratio; immune–haematological parameters; M. tuberculosis complex and helminth coinfection
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines12071472

The effect of helminthiasis on host immunity is a neglected area of research, particularly in tuberculosis (TB) infection. This study aimed to evaluate the effect of helminthiasis on immunological and haematological parameters in newly diagnosed TB patients in Bobo-Dioulasso. After all biological analyses, we formed three subpopulations: group 1 (
= 82), as control, were participants without helminthic or
complex infection (
-/Helm-), group 2 (
= 73) were TB patients without helminthic infection (
+/Helm-), and group 3 (
= 22) were TB patients with helminthic infection (
+/Helm+). The proportion of helminth coinfection was 23.16% (22/95) in TB patients, and
infection was found in 77.3% (17/22) cases of helminthiasis observed in this study. A low CD4 T cell count and a low CD4:CD8 ratio were significantly associated with concomitant infection with helminths and the
complex (
+/Helm+) compared to the other groups (
< 0.05). However, there was no statistically significant difference in the CD8 median among the three participating groups (
> 0.05). Lymphopenia, monocytosis, thrombocytosis, and hypochromic microcytic anaemia were the haematological defects observed in the
/Helm+ and
/Helm- patients. Exploring these types of immune-haematological biomarkers would be a valuable aid in diagnosing and a better follow-up and monitoring of the tuberculosis-helminthiasis coinfection.