Synthesis and Antimicrobial Activity of Amphiphilic Copolymer Derivatives

• Published in: Polymers & polymer composites Vol. 19; no. 7; pp. 611 - 618
• Main Authors: Bai, Yongxiao, Liu, Yaobin, Li, Yanfeng, Changa, Caiping, Zhang, Qi
• Format: Journal Article
• Language: English
• Published: Shrewsbury Rapra 01-09-2011; Sage Publications Ltd. (UK); Sage Publications Ltd
• Subjects: Antimicrobial agents; Applied sciences; Bacillus; Biosynthesis; Chemical modifications; Chemical reactions and properties; Chemical synthesis; Copolymers; Escherichia coli; Exact sciences and technology; Materials science; Methods; Monilia; Organic polymers; Physicochemistry of polymers; Studies; Styrene; China; Biological properties; Property composition relationship; Quaternary ammonium copolymer; Experimental study; Antimicrobial agent; Bactericidal effect; Chemical modification; Glycidyl methacrylate copolymer; Amination; Preparation; Acetylation; Methacrylate copolymer; Amphiphilic polymer; Styrene copolymer
• ISSN: 0967-3911; 1478-2391
• DOI: 10.1177/096739111101900712

A series of antimicrobial amphiphilic quaternized copolymers are synthesized through glycidyl methacrylate and styrene after poly(glycidyl methacrylate- co-styrene) modified by introduction of chloroethylic groups using chloroacetyl chloride. The antimicrobial activity of the obtained copolymers was evaluated against the gram-negative bacteria Escherichia coli, the gram-positive bacteria Bacillus subtilus, Staphyloccocus aureus Rosenbach and the fungus Monilia albican by the cut-plug method and Luria-Bertani broth suspended method. The research showed that the copolymer with the molar ratio of monomers 30:70 was the most effective against the microorganisms. The minimum inhibitory concentration (MIC) values of the polymer with against Staphyloccocus aureus Rosenbach and Monilia albican were found to be 31.3 and 32.1 μg/mL, respectively, and these copolymers did not have any haemolytic action for mammalian erythrocytes.