Role of reactive oxygen species (ROS) in apoptosis induction

Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largel...

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Bibliographic Details
Published in:	Apoptosis (London) Vol. 5; no. 5; pp. 415 - 418
Main Authors:	Simon, H U, Haj-Yehia, A, Levi-Schaffer, F
Format:	Journal Article
Language:	English
Published:	Netherlands Springer Nature B.V 01-11-2000
Subjects:	Animals Apoptosis Apoptosis - physiology Cells Humans Mitochondria Reactive Oxygen Species - physiology
Online Access:	Get full text
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Summary:	Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1360-8185 1573-675X
DOI:	10.1023/A:1009616228304