Voltammetric Determination of an Anti‐rheumatoid Drug Acemetacin on Graphite Flake Paste Electrode and Glassy Carbon Electrode

• Published in: Electroanalysis (New York, N.Y.) Vol. 33; no. 2; pp. 314 - 322
• Main Authors: Festinger, Natalia, Smarzewska, Sylwia, Mirčeski, Valentin, Ciesielski, Witold
• Format: Journal Article
• Language: English
• Published: 01-02-2021
• Subjects: acemetacin; electrochemistry; glassy carbon electrode; graphite flake paste electrode; voltammetry
• ISSN: 1040-0397; 1521-4109
• DOI: 10.1002/elan.202060267

In this study, a simple and sensitive square wave voltammetric procedure has been developed for the determination of acemetacin (ACM) at graphite flake paste electrode (GFPE) and glassy carbon electrode (GCE). Under optimized conditions, the dependence of ACM peak current on its concentration showed wide linear range: 0.03–1.0 μmol L−1 and 0.7–15.0 μmol L−1 at GFPE and GCE, respectively. The developed method was successfully applied for the determination of ACM in pharmaceuticals and spiked urine with satisfying recoveries. The electrochemical oxidation of ACM is an irreversible process controlled by mixed nature of the mass transfer process.