Topical antiinflammatory activity of an innovative aqueous formulation of actichelated® propolis vs two commercial propolis formulations

• Published in: Phytotherapy research Vol. 21; no. 9; pp. 823 - 826
• Main Authors: Sosa, Silvio, Bornancin, Anna, Tubaro, Aurelia, Loggia, Roberto Della
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01-09-2007; Wiley
• Subjects: actichelated® propolis; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Bees; Biological and medical sciences; Chemistry, Pharmaceutical; Croton Oil; croton oil ear test; Dose-Response Relationship, Drug; Edema - chemically induced; Edema - prevention & control; General pharmacology; Medical sciences; Mice; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; propolis; Propolis - administration & dosage; Propolis - chemistry; Propolis - pharmacology; Propolis - therapeutic use; spray formulation; topical antiinflammatory activity; mice; Medicinal plant; Local administration; Folk medicine; Dicotyledones; Formulation; Angiospermae; Euphorbiaceae; actichelated® propolis; spray formulation; Pharmacognosy; Propolis; Rodentia; Antiinflammatory agent; Animal origin; croton oil ear test; Vertebrata; Mammalia; Oil; topical antiinflammatory activity; Mouse; Animal; Ear; Plant origin; Spermatophyta; Topical administration
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.2206

A novel aqueous commercial formulation of a new hydrophilic propolis product (Actichelated® Propolis, contained in 'LeniGola PropolEffect Spray Senza Alcohol'; Pharbenia, Milan, Italy) was evaluated for its topical antiinflammatory activity in comparison with a hydroglyceric propolis spray solution ('Propoli LeniGola Spray Senza Alcool'; Pharbenia, Milan, Italy) and a hydroalcohol preparation ('Propoli LeniGola Spray Forte'; Pharbenia, Milan, Italy). Actichelated® propolis (Actimex, Trieste, Italy) is a multicomposite material obtained with a patented technology, mechano-chemical activation, which application led to a new hydrosoluble form of propolis.Each propolis preparation provoked a dose-dependent inhibition of the croton oil-induced ear oedema in mice. Considering the administered doses of flavonoids, 'LeniGola PropolEffect Spray Senza Alcool' (ID₅₀ = 13.6 μL/cm², corresponding to 13.6 μg flavonoids/cm²) is slightly more active than the hydroglyceric formulation 'Propoli LeniGola Spray' (ID₅₀ = 13.7 μL/cm², corresponding to 20.6 μg flavonoids/cm²) and six times more active than the hydroalcohol preparation 'Propoli LeniGola Spray Forte' (ID₅₀ = 5.5 μL/cm², corresponding to 82.5 μg flavonoids/cm²). As a reference, 15 μL/cm² of the commercial sprays Tantum® Verde and Froben®, containing 37.5 or 45 μg of the non-steroidal antiinflammatory drugs benzidamine hydrochloride or flurbiprofen, induced 18% and 35% oedema inhibition, respectively. Copyright © 2007 John Wiley & Sons, Ltd.