Calixarene/carbon nanotubes based screen printed sensors for potentiometric determination of gentamicin sulphate in pharmaceutical preparations and spiked surface water samples

• Published in: Sensors and actuators. B, Chemical Vol. 244; pp. 876 - 884
• Main Authors: Khaled, Elmorsy, Khalil, M.M., Abed el Aziz, G.M.
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier B.V 01-06-2017; Elsevier Science Ltd
• Subjects: Calixarene; Calixarenes; Carbon nanotubes; Chemical compounds; Disposable potentiometric sensor; Gentamicin sulphate (GNS); Multi wall carbon nanotubes; Nanotubes; Pharmaceutical analysis; Pharmaceutical sciences; Polyvinyl chloride; Response time; Sensors; Surface water; Surface water samples; Carbon nanotubes; Disposable potentiometric sensor; Calixarene; Surface water samples; Pharmaceutical analysis; Gentamicin sulphate (GNS)
• ISSN: 0925-4005; 1873-3077
• DOI: 10.1016/j.snb.2017.01.033

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•Novel gentamicin screen printed sensor based calixarene/multi-walled carbon nanotubes/PVC composite was introduced.•Improved sensitivity and selectivity was achieved with molecular host–guest recognition elements in presence of CNTs.•Linear response in the concentration range from 10−7 to 10−2molL−1 with fast response time and long operational lifetime.•Relative simple fabrication protocol with high reproducibility offer promising approaches for drug quality control.
Sensitive disposable sensors have been introduced for potentiometric determination of gentamicin sulphate (GNS) based on multi-walled carbon nanotubes–polyvinyl chloride (MWNTs–PVC) composite in presence of calixarene as a molecular recognition element. The proposed sensors showed remarkable selectivity and sensitivity in the GNS concentration range from 10−7 to 10−2molL−1 with Nernstian slope 30.5±0.4mVdecade−1 and detection limit of 7.5×10−8molL−1. Modification with carbon nanotubes improved the sensors performance was through promotion of the electron-transfer processes and enhancing the stability of potential reading, response time, and shelf lifetime of sensors. The proposed method has been applied for the potentiometric assay of GNS in different dosage forms and spiked surface water samples with average recoveries agreeable with the reported official method.