Conicaquinones A and B, Two Novel Cytotoxic Terpene Quinones from the Mediterranean Ascidian Aplidium conicum

Two new unique cytotoxic metabolites, conicaquinones A (1) and B (2), each possessing a 1,1‐dioxo‐1,4‐thiazine ring, were isolated from the Mediterranean ascidian Aplidium conicum. Their structures were established by an extensive spectroscopic analysis. Compounds 1 and 2 exhibited a strong cytotoxi...

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Bibliographic Details
Published in:	European journal of organic chemistry Vol. 2003; no. 5; pp. 898 - 900
Main Authors:	Aiello, Anna, Fattorusso, Ernesto, Luciano, Paolo, Menna, Marialuisa, Esposito, Giuseppe, Iuvone, Teresa, Pala, David
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 01-03-2003 WILEY‐VCH Verlag
Subjects:	Ascidians Natural products Quinones Terpenoids Thiazinoquinones
Online Access:	Get full text
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Summary:	Two new unique cytotoxic metabolites, conicaquinones A (1) and B (2), each possessing a 1,1‐dioxo‐1,4‐thiazine ring, were isolated from the Mediterranean ascidian Aplidium conicum. Their structures were established by an extensive spectroscopic analysis. Compounds 1 and 2 exhibited a strong cytotoxicity in vitro against rat glioma cells. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
Bibliography:	ark:/67375/WNG-ZLW6RX1X-0 istex:4E862C6DABDB148A45C2C9D05E82AE308129A1D0 ArticleID:EJOC200390136
ISSN:	1434-193X 1099-0690
DOI:	10.1002/ejoc.200390136