Treatment of Multifocal Multisystem BRAF Positive Langerhans Cell Histiocytosis with Cladribine, Surgery and Allogenic Stem Cell Transplantation

Treatment of Multifocal Multisystem BRAF Positive Langerhans Cell Histiocytosis with Cladribine, Surgery and Allogenic Stem Cell Transplantation

Langerhans cell histiocytosis (LCH) is a very rare disease in adults and as well a very rare cause of sellar expansion. The clinical presentation can be heterogeneous, from a single bone lesion to potentially fatal, widespread disease. We describe the difficulties with the diagnosis and treatment of...

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Bibliographic Details
Published in:Acta medica Lékarskí fakulty Univerzity Karlovy v Hradci Králove Vol. 60; no. 4; pp. 152 - 156
Main Authors: Gabalec, Filip, Šimkovič, Martin, Zavřelová, Alžběta, Kašparová, Petra, Morávková, Paula, Kopáčová, Marcela, Masopust, Václav, Žák, Pavel, Čáp, Jan, Radocha, Jakub
Format: Journal Article
Language:English
Published: Czech Republic Karolinum Press 01-01-2017
Subjects:
cladribine
histiocytosis
hypopituitarism
stem cell
transplantation
hypopituitarism
stem cell
cladribine
histiocytosis
transplantation
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Summary:Langerhans cell histiocytosis (LCH) is a very rare disease in adults and as well a very rare cause of sellar expansion. The clinical presentation can be heterogeneous, from a single bone lesion to potentially fatal, widespread disease. We describe the difficulties with the diagnosis and treatment of LCH as well as successful treatment with cladribine chemotherapy and allogeneic stem cell transplantation.
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ISSN:1211-4286
1805-9694
DOI:10.14712/18059694.2018.11