The skin redoxome

Redoxome is the network of redox reactions and redox active species (ReAS) that affect the homeostasis of cells and tissues. Due to the intense and constant interaction with external agents, the human skin has a robust redox signalling framework with specific pathways and magnitudes. The establishme...

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Bibliographic Details
Published in:	Journal of the European Academy of Dermatology and Venereology Vol. 36; no. 2; pp. 181 - 195
Main Authors:	Schalka, S., Silva, M.S., Lopes, L.F., Freitas, L.M., Baptista, M.S.
Format:	Journal Article
Language:	English
Published:	England 01-02-2022
Subjects:	Homeostasis Humans Oxidation-Reduction Reactive Oxygen Species Signal Transduction
Online Access:	Get full text
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Summary:	Redoxome is the network of redox reactions and redox active species (ReAS) that affect the homeostasis of cells and tissues. Due to the intense and constant interaction with external agents, the human skin has a robust redox signalling framework with specific pathways and magnitudes. The establishment of the skin redoxome concept is key to expanding knowledge of skin disorders and establishing better strategies for their prevention and treatment. This review starts with its definition and progress to propose how the master redox regulators are maintained and activated in the different conditions experienced by the skin and how the lack of redox regulation is involved in the accumulation of several oxidation end products that are correlated with various skin disorders.
Bibliography:	Conflicts of interest The authors disclaim no conflict of interest. Funding source MSB acknowledges FAPESP (grant # 2013/07937‐8) and CNPq (grant # 303831/2019‐7). ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0926-9959 1468-3083
DOI:	10.1111/jdv.17780